Optimal collision-free formation control of the unmanned aerial vehicle (UAV) is a challenge. The state-of-the-art optimal control approaches often rely on numerical methods sensitive to initial guesses. This paper presents an innovative collision-free finite-time formation control scheme for multiple UAVs leveraging the differential flatness of the UAV dynamics, eliminating the need for numerical methods. We formulate a finite-time optimal control problem to plan a formation trajectory for feasible initial states. This optimal control problem in formation trajectory planning involves a collective performance index to meet the formation requirements to achieve relative positions and velocity consensus. It is solved by applying Pontryagin's principle. Subsequently, a collision-constrained regulating problem is addressed to ensure collision-free tracking of the planned formation trajectory. The tracking problem incorporates a directionally aware collision avoidance strategy that prioritizes avoiding UAVs in the forward path and relative approach. It assigns lower priority to those on the sides with an oblique relative approach, disregarding UAVs behind and not in the relative approach. The high-fidelity simulation results validate the effectiveness of the proposed control scheme.

Identifying governing equations in physical and biological systems from datasets remains a long-standing challenge across various scientific disciplines, providing mechanistic insights into complex system evolution. Common methods like sparse identification of nonlinear dynamics (SINDy) often rely on precise derivative estimations, making them vulnerable to data scarcity and noise. This study presents a novel data-driven framework by integrating high order implicit Runge-Kutta methods (IRKs) with the sparse identification, termed IRK-SINDy. The framework exhibits remarkable robustness to data scarcity and noise by leveraging the lower stepsize constraint of IRKs. Two methods for incorporating IRKs into sparse regression are introduced: one employs iterative schemes for numerically solving nonlinear algebraic system of equations, while the other utilizes deep neural networks to predict stage values of IRKs. The performance of IRK-SINDy is demonstrated through numerical experiments on benchmark problems with varied dynamical behaviors, including linear and nonlinear oscillators, the Lorenz system, and biologically relevant models like predator-prey dynamics, logistic growth, and the FitzHugh-Nagumo model. Results indicate that IRK-SINDy outperforms conventional SINDy and the RK4-SINDy framework, particularly under conditions of extreme data scarcity and noise, yielding interpretable and generalizable models.

Premature coronary artery disease (PCAD) refers to the early onset of the disease, usually before the age of 55 for men and 65 for women. Coronary Artery Disease (CAD) develops when coronary arteries, the major blood vessels supplying the heart with blood, oxygen, and nutrients, become clogged or diseased. This is often due to many risk factors, including lifestyle and cardiometabolic ones, but few studies were done on ethnicity as one of these risk factors, especially in PCAD. In this study, we tested the rank of ethnicity among the major risk factors of PCAD, including age, gender, body mass index (BMI), visceral obesity presented as waist circumference (WC), diabetes mellitus (DM), high blood pressure (HBP), high low-density lipoprotein cholesterol (LDL-C), and smoking in a large national sample of patients with PCAD from different ethnicities. All patients who met the age criteria underwent coronary angiography to confirm CAD diagnosis. The weight of ethnicity was compared to the other eight features using feature weighting algorithms in PCAD diagnosis. In addition, we conducted an experiment where we ran predictive models (classification algorithms) to predict PCAD. We compared the performance of these models under two conditions: we trained the classification algorithms, including or excluding ethnicity. This study analyzed various factors to determine their predictive power influencing PCAD prediction. Among these factors, gender and age were the most significant predictors, with ethnicity being the third most important. The results also showed that if ethnicity is used as one of the input risk factors for classification algorithms, it can improve their efficiency. Our results show that ethnicity ranks as an influential factor in predicting PCAD. Therefore, it needs to be addressed in the PCAD diagnostic and preventive measures.

Ischemic stroke, caused by cerebral vessel occlusion, presents substantial challenges in medical imaging due to the variability and subtlety of stroke lesions. Magnetic Resonance Imaging (MRI) plays a crucial role in diagnosing and managing ischemic stroke, yet existing segmentation techniques often fail to accurately delineate lesions. This study introduces a novel deep learning-based method for segmenting ischemic stroke lesions using multi-channel MRI modalities, including Diffusion Weighted Imaging (DWI), Apparent Diffusion Coefficient (ADC), and enhanced Diffusion Weighted Imaging (eDWI). The proposed architecture integrates DenseNet121 as the encoder with Self-Organized Operational Neural Networks (SelfONN) in the decoder, enhanced by Channel and Space Compound Attention (CSCA) and Double Squeeze-and-Excitation (DSE) blocks. Additionally, a custom loss function combining Dice Loss and Jaccard Loss with weighted averages is introduced to improve model performance. Trained and evaluated on the ISLES 2022 dataset, the model achieved Dice Similarity Coefficients (DSC) of 83.88% using DWI alone, 85.86% with DWI and ADC, and 87.49% with the integration of DWI, ADC, and eDWI. This approach not only outperforms existing methods but also addresses key limitations in current segmentation practices. These advancements significantly enhance diagnostic precision and treatment planning for ischemic stroke, providing valuable support for clinical decision-making.

Graphs, comprising nodes and edges, visually depict relationships and structures, posing challenges in extracting high-level features due to their intricate connections. Multiple connections introduce complexities in discovering patterns, where node weights may affect some features more than others. In domains with diverse topics, graph representations illustrate interrelations among features. Pattern discovery within graphs is recognized as NP-hard. Graph Convolutional Networks (GCNs) are a prominent deep learning approach for acquiring meaningful representations by leveraging node connectivity and characteristics. Despite achievements, predicting and assigning 9 deterministic classes often involves errors. To address this challenge, we present a multi-stage non-deterministic classification method based on a secondary conceptual graph and graph convolutional networks, which includes distinct steps: 1) leveraging GCN for the extraction and generation of 12 high-level features: 2) employing incomplete, non-deterministic models for feature extraction, conducted before reaching a definitive prediction: and 3) formulating definitive forecasts grounded in conceptual (logical) graphs. The empirical findings indicate that our proposed approach outperforms contemporary methods in classification tasks. Across three datasets Cora, Citeseer, and PubMed the achieved accuracies are 96%, 93%, and 95%, respectively. Code is available at https://github.com/MasoudKargar.

Opposition-based learning (OBL) is an effective approach to improve the performance of metaheuristic optimization algorithms, which are commonly used for solving complex engineering problems. This chapter provides a comprehensive review of the literature on the use of opposition strategies in metaheuristic optimization algorithms, discussing the benefits and limitations of this approach. An overview of the opposition strategy concept, its various implementations, and its impact on the performance of metaheuristic algorithms are presented. Furthermore, case studies on the application of opposition strategies in engineering problems are provided, including the optimum locating of control systems in tall building. A shear frame with Magnetorheological (MR) fluid damper is considered as a case study. The results demonstrate that the incorporation of opposition strategies in metaheuristic algorithms significantly enhances the quality and speed of the optimization process. This chapter aims to provide a clear understanding of the opposition strategy in metaheuristic optimization algorithms and its engineering applications, with the ultimate goal of facilitating its adoption in real-world engineering problems.

Deep Learning (DL) has shown promise for downscaling global climate change projections under different approaches, including Perfect Prognosis (PP) and Regional Climate Model (RCM) emulation. Unlike emulators, PP downscaling models are trained on observational data, so it remains an open question whether they can plausibly extrapolate unseen conditions and changes in future emissions scenarios. Here we focus on this problem as the main drawback for the operationalization of these methods and present the results of 1) a literature review to identify state-of-the-art DL models for PP downscaling and 2) an intercomparison experiment to evaluate the performance of these models and to assess their extrapolation capability using a common experimental framework, taking into account the sensitivity of results to different training replicas. We focus on minimum and maximum temperatures and precipitation over Spain, a region with a range of climatic conditions with different influential regional processes. We conclude with a discussion of the findings, limitations of existing methods, and prospects for future development.

It is acknowledged that the most common cause of dementia worldwide is Alzheimer's disease (AD). This condition progresses in severity from mild to severe and interferes with people's everyday routines. Early diagnosis plays a critical role in patient care and clinical trials. Convolutional neural networks (CNN) are used to create a framework for identifying specific disease features from MRI scans Classification of dementia involves approaches such as medical history review, neuropsychological tests, and magnetic resonance imaging (MRI). However, the image dataset obtained from Kaggle faces a significant issue of class imbalance, which requires equal distribution of samples from each class to address. In this article, to address this imbalance, the Synthetic Minority Oversampling Technique (SMOTE) is utilized. Furthermore, a pre-trained convolutional neural network has been applied to the DEMNET dementia network to extract key features from AD images. The proposed model achieved an impressive accuracy of 98.67%.

Neural networks are often regarded as "black boxes" due to their complex functions and numerous parameters, which poses significant challenges for interpretability. This study addresses these challenges by introducing methods to enhance the understanding of neural networks, focusing specifically on models with a single hidden layer. We establish a theoretical framework by demonstrating that the neural network estimator can be interpreted as a nonparametric regression model. Building on this foundation, we propose statistical tests to assess the significance of input neurons and introduce algorithms for dimensionality reduction, including clustering and (PCA), to simplify the network and improve its interpretability and accuracy. The key contributions of this study include the development of a bootstrapping technique for evaluating artificial neural network (ANN) performance, applying statistical tests and logistic regression to analyze hidden neurons, and assessing neuron efficiency. We also investigate the behavior of individual hidden neurons in relation to out-put neurons and apply these methodologies to the IDC and Iris datasets to validate their practical utility. This research advances the field of Explainable Artificial Intelligence by presenting robust statistical frameworks for interpreting neural networks, thereby facilitating a clearer understanding of the relationships between inputs, outputs, and individual network components.

Predicting unknown drug-drug interactions (DDIs) is crucial for improving medication safety. Previous efforts in DDI prediction have typically focused on binary classification or predicting DDI categories, with the absence of explanatory insights that could enhance trust in these predictions. In this work, we propose to generate natural language explanations for DDI predictions, enabling the model to reveal the underlying pharmacodynamics and pharmacokinetics mechanisms simultaneously as making the prediction. To do this, we have collected DDI explanations from DDInter and DrugBank and developed various models for extensive experiments and analysis. Our models can provide accurate explanations for unknown DDIs between known drugs. This paper contributes new tools to the field of DDI prediction and lays a solid foundation for further research on generating explanations for DDI predictions.